This story introduces Takeru who is an average Japanese highschool girl raised in a Buddhist convent by nuns. She has been experiencing reoccurring nightmares about the Witchblade calling out to her. This is due to the secret that the temple houses within, the Witchblade sealed inside a box. Furthermore, her lineage keeps an unknown connection with the mystic artifact and the folklore of the Oni, hence explaining Takeru's strong attraction to the gauntlet which is locally called Oni no te (鬼の手, "Hand of Oni"). Ultimately, Takeru's life suffers a drastic change when she becomes the next bearer of the Witchblade due to some circumstances that force her to randomly encounter it.

Witchblade Takeru started serial run since March 2006 in Champion Red magazine under publisher Akita Shoten. Story by Kobayashi Yasuko with art made by Sumita Kazasa, whose art and illustrations carry over an erotic style.

Based on Marc Silvestri's and David Wohl's American Comic book series.